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Cell culture reagents: DMEM (Gibco, 31966), penicillin/streptomycin (Gibco, 15140-122), Opti-MEM (Gibco, 51985), non-essential amino acids (Gibco, 11140), Insulin (Merk, 19278), IBMX (#I5979, SIGMA), and dexamethasone (#D4902, SIGMA), collagen IV (#C5533, SIGMA)