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The role of hypoxia-inducible factors in carotid body (patho) physiology

Matuz-Mares D, Riveros-Rosas H, Vilchis-Landeros MM, Vazquez-Meza H

These oxidatively modified proteins can acquire neoantigen properties - meaning the immune system no longer recognizes them as "self" and mounts an antibody response against them

In the heart, the metabolome is characterized by amino acid depletion, evidence of altered redox balance including glutathione depletion, and a shift from oxidative phosphorylation to alternative energy production pathways