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Supplementary information is available at Cell Death & Disease s website

Using functional and histological approaches, lipidomics, and transcriptomics, we reveal that TAN-fed mice show improved systemic lipid catabolism and energy expenditure, thus funneling lipid away from the liver

For thiopurines, the complex biotransformation pathway of azathioprine and 6-mercaptopurine is implicated and the association between TPMT gene alleles and the metabolism rate was significant and was approved by the FDA as the first main pharmacogenetic biomarker [37]

In cases where blood vessels malfunction, like in DR, FSP1 may play a role in controlling the growth of extra blood vessels and the formation of tough scar tissue by communicating with growth factors and the cell surface receptors, which in turn affects how the extracellular matrix changes and the series of events that lead to new blood vessel formation