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Research suggests that the abdomen may be the least painful place for a subcutaneous injection, but this may vary for each individual

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However, as with any biological therapy, the theoretical possibility of individual hypersensitivity cannot be entirely eliminated, and appropriate monitoring remains prudent

[199] A research letter published in JAMA reported that the vaccines appeared to be safe for immunosuppressed organ transplant recipients, but that the resulting antibody response was considerably poorer than in the non-immunocompromised population after only one dose