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Description

Tumor-intrinsic mechanisms include loss of antigen presentation (such as mutations in human leukocyte antigen or 2-microglobulin), activation of alternative immune checkpoints (such as T-Cell immunoglobulin and mucin domain 3 or lymphocyte activating 3) and upregulation of immunosuppressive signaling pathways (such as TGF- or indoleamine 2,3-dioxygenase) (136138)