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Specifically, mitochondria have been linked to oxidative stress and subsequent inflammatory processes in a wide range of pathological conditions (Table 3, suggested a deficiency in oxidative stress defense as well as an increased lipid peroxidation, results already reported in FM and even linked to pain intensity and inflammation in those patients ( - rated canonical pathways according to the p- value were complement cascade and complement system, implying proteins such as CO4B (FM/C ratio: 0.86), CO8B (FM/C ratio: 0.89), CO8G (FM/C ratio: 0.81), CFAH (FM/C ratio: 1.15), and IGKC (FM/C ratio: 0.78)

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J Internal Med (2015) 277:71726