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Elevated blood concentrations of homocysteine have been considered for many years to be a risk factor for some chronic diseases, including cardiovascular disease and dementia (see Disease Prevention)

8,9,2527,3439,68,69 The gliadin p31-43 peptide induces cellular stress, activates proliferative mechanisms of cryptic epithelial cells, drives enterocyte stress, induces a Ca 2+ surge (thus activating the CD autoantigen tTG), triggers a local pro-inflammatory storm, activates the NFB signaling pathway, inhibits CFTR (cystic fibrosis transmembrane conductance regulator, an ion channel protein), alters vesicular trafficking, activates the inflammasome platform, and reduces autophagy

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