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Depending on the extent of the cancer, surgical procedures may range from minimally invasive techniques to more extensive operations such as a laryngectomy, where part or all of the voice box is removed

Heterogeneity in meta-analysis was evaluated using the I 2 test and classified as low ( 25%), moderate (50%), or high ( 75%).19 A fixed-effects model was used in cases when I 2 was lower than 50%, whereas if I 2 was greater than 50%, the random-effects model was used