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Female 5xFAD mice that express human APOE4 (E4FAD) exhibit increased anxiety-like behavior relative to E3FAD, and ovariectomy (OVX) in E3FAD mice increases anxiety to a similar level to intact and OVXed E4FAD mice, suggesting a protective role of ovarian hormones against anxiety-like phenotypes in E3FAD but not E4FAD mice (Taxier et al., 2022)

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As a general rule we would like the bottom lip to be one and a half times the size of the upper lip (or 40/60, upper to lower lip), though we can create other proportions, if the patient requests (a lip ratio of 1:1 is more popular in Latin America, and can create a beautiful, natural lip profile for many patients)

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