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For instance, two recent studies have identified GPT2-mediated coupling of pyruvate production to glutamine catabolism in two different tissue types: PIK3CA-mutated colorectal cancer cells (Hao et al, 2016), and Ras- and p53-transformed YMAC cells (Smith et al, 2016)

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Because of the structural characteristics of 4-OXO-DHA (Michael acceptor), not shared by any of the other hydroxylated-DHA, we used MS and showed that it can covalently modify the cysteine residue of NF-B