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TABLE 1 Summary of SRM transitions used for LC-MS/MS analysis of Deg-AZM and IS

These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying

2.1.8 Mangiferin Mangiferin is a natural flavonoid compound found mainly in mangoes

As with many natural spices consumed in South Asian and Middle Eastern countries, turmeric would have been (and continues to be) regularly consumed, in amounts reaching several grams daily, with benefits being conferred over many years of consumption