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The peptide enhances TGF-beta receptor expression and increases cellular responsiveness to TGF-beta ligands, amplifying SMAD2/3 phosphorylation and nuclear translocation

In a double-blind study with a placebo group, chronic insomniac patients administered with a DSIP analogue experienced a reduction in sleep latency by an average of 22 minutes, suggesting its potential as a therapeutic agent for severe chronic insomnia patients (Anderer & Saletu, 1991)

Inversely, the simultaneous administration of AST partially attenuated FPN impacts, ameliorating the severity of FPN-induced neuronal damage

Due to their roles as effector molecules these are often termed as bioactive lipid mediators