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94 In rats, with the ligation of the inferior caval vein, direct vein injury and thrombosis were counteracted (occlusion up to the right ovarian vein leading to vessel injury, stasis, thrombosis and hemodynamic changes a recapitulation of Virchow)

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In the STEP 1 trial with 1,961 participants, patients taking 2.4 mg semaglutide weekly alongside reduced caloric intake and increased physical activity lost an average of 14.9% of their body weight over 68 weeks