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In the feet, this can lead to: Tingling or pins and needles sensations Numbness or reduced ability to feel pain, heat, or cold Burning or shooting pain, especially at night Muscle weakness or instability when walking Neuropathy often develops gradually, and without early treatment, it can worsen over timeincreasing your risk of injuries, ulcers, and infections

Padarian et al

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Drug/Laboratory Test Interactions Most antibiotics, methotrexate, and pyrimethamine invalidate folic acid and vitamin B12 diagnostic microbiological blood assays