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However, Aja and colleagues found no evidence for this hypothesis since in this model CPT-1 should inhibit feeding by increasing cytosolic fatty-acyl CoA levels while they actually showed the initial response of mice to a CPT-1 inhibitor was an increase in appetite [75]

FIGURE 4 FIGURE 5 3.3 L-carnitine counteracted lenvatinib-induced protein synthesis inhibition in C2C12 myocytes We have shown that lenvatinib inhibits global protein synthesis in C2C12 myocytes at concentrations 100 nM, which is equivalent to the trough plasma concentration in patients with HCC (Okubo et al., 2022), in C2C12 myocytes (Jing et al., 2022)