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Description

Ixabepilone-induced mitochondria and sensory axon loss in breast cancer patients

Autophagy 6:10901106

Zhang WW, Feng Z, J

To pharmacologically inhibit the acetyltransferase activity of p300, we developed IACS-16898 37 , an orally available inhibitor targeting the bromodomains of p300/CBP, and tested whether pharmacological targeting of this downstream pathway could restore sensitivity to ICT in our immunocompetent mouse model of RMC