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These observations have led to the recommendation that children and adolescents should aim for near-normal glycaemia and this should be achieved as early as possible

10.1016/j.foodchem.2021.130671 279 ZhangX.GuoX.SunJ.ChenY.ZhangM.TangX.et al (2024c)

Severe hyperglycaemia may induce glucotoxicity in selective neurons involved in cognitive processing, with hippocampal neurons having been identified as particularly vulnerable to hyperglycaemia, and with proposed mechanisms including mitochondrial dysfunction and inflammatory responses [35]

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