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Methods: We first employed a modeling selection approach to identify a mathematical model that best reproduced the observed multiphasic serum HBV kinetics from de-novo infection to a steady state of viremia in humanized mice (Hepatology

.Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trialJ Hepatol.2005436306 140

Much of the initial focus of irAE identification and management was on rash, colitis, and endocrinopathies, in part because these are more common and in part because they can be associated with significant morbidity