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4 [6, 128], it mainly contains the following pathways: (1) through the tears and cornea into the anterior chamber, (2) non-corneal permeation into the anterior uvea through the conjunctiva and sclera, (3) drug from the bloodstream cross BAB to the anterior chamber, (4) drug from the aqueous humor cross BAB to the systemic circulation, (5) drug elimination from the aqueous humor to the trabecular meshwork and Schlemm's canal, (6) drug distribution from the circulation through BRB to the posterior segment of the eye, (7) intravitreal administration, (8) elimination from the vitreous body into the posterior compartment via an anterior route, and (9) elimination from the vitreous body via a posterior route through BRB

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