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This anti-metastatic effect was due to the activation of the SP1/caveoli-1 signalling pathway (112, 113)

Another study reported that purines from hepatic macrophages could modulate the activation of NLRP3 inflammasomes through the purinergic receptor P2X7, exerting a significant influence on the progression of ALD and potentially serving as a fresh target for future ALD therapy (Le Dare et al., 2021)