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Description

May cause redistribution of coronary blood flow from normal to ischemic tissue Nitrates (and calcium channel blockers) may also increase myocardial oxygen delivery in variant angina by reversing coronary arterial spasm Indications: Sublingual nitroglycerin is the drug of choice for acute treatment of angina due to its rapid onset of action & clinical efficacy Classic Effort-induced Angina pectoris Venodilation with resulting decreased venous return to the heart and the resulting reduction of intracardiac volume result in decreased wall tension (LaPlace relation) & decreased preload result in decreased myocardial oxygen demand

"Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse." American Journal of Physiology-Endocrinology and Metabolism