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doi: 10.1038/nri1457 81 PlattenMHoPPYoussefSFontouraPGarrenHHurEMet al

Studies have shown that between six and thirty percent of people with type 2 diabetes who are taking more than 1,500 mg of metformin could have low B12 levels

[52] Role in heart function In adult mice, MET is required to protect cardiomyocytes by preventing age-related oxidative stress, apoptosis, fibrosis and cardiac dysfunction