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FIGURE 3 6 Conclusion Ferroptosis, a recently discovered form of regulated cell death, is driven by iron-dependent lipid peroxidation and involves intricate molecular mechanisms

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S32 phosphorylation of RIPK1 prevents its activation and TNF-induced cell death To investigate the function of S32 phosphorylation in regulating RIPK1 activity and cell death, we reconstituted RIPK1-deficient MEFs with WT RIPK1, S32A mutant, and the phospho-mimetic S32E mutant

Recently, using chimeric receptors, we have demonstrated how domain differences between IR and IGF1R contribute to the distinct functions of these receptors (14)