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Description

This helix forms a lid over the active site when the hydrophobic substrate binding site (H-site) is occupied but it is otherwise disordered

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while its continuous activation in T cells induces pyroptosis by inhibiting the peroxisome proliferator-activated receptor (PPAR)-nuclear factor erythroid 2-related factor 2 (Nrf2) axis, leading to immunosuppression (54)

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Modulates over 4,000 human genes and stimulates collagen synthesis by up to 70%

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This reveals the cysteine-GSH-RSS metabolic network as an adaptive defense system sensing environmental danger signals

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