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Reaches the upper papillary dermis without engaging deeper vascular structures

HeLa cells were also used as a tumor cell model, and in vivo and in vitro experiments suggested that under X-ray irradiation, CeO 2 MnO 2 exerted a positive anti-tumor effect by generating massive ROS in the cells, leading to a flip in mitochondrial membrane potential and accelerating apoptosis of tumor cells (Scheme 1)

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The off-period gives the body a chance to reset baseline NNMT activity