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SKU: 89673591086
Price: 21.85 USD
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Description

Acquired Secondary RAS Mutation in BRAFV600E-Mutated Thyroid Cancer Patients Treated with BRAF Inhibitors

Upton, T

After exposure to electrophilic or oxidative stress, the sensor residues cysteine of Keap1, especially C151, C226, C273, and C288, undergo oxidation and modification, causing conformational changes that inhibit Keap1-mediated NRF2 degradation [94]