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At 52 weeks, a reduction in circulating volume and blood pressure is observed, associated with decreased levels of adipokines and aldosterone, alongside reduced albuminuria and increased glomerular filtration rate compared with placebo, suggesting an additional renal benefit.47 GIP antagonist - GLP-1 agonist: MariTida This drug (Maridebart-cafraglutide or AMG 133), which is a conjugate of a monoclonal antibody to the GIP receptor and two GLP-1 receptor agonist molecules, is effective in reducing body weight in obese mice and cynomolgus monkeys

The availability of nutrients in the circulation might also have a direct effect on the production of IGF-I

Zirngibl et al., 2022) We suspect that the high energy requirement of OLs to maintain their myelin sheaths may be one reason why they extremely susceptible to CPZ

For this review, outside of these studies, unless stated otherwise, all other cuprizone research mentioned is carried out in mice