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In addition, senile plaques may also contain mucopolysaccharides, 1-antiquimiotripsin, immunoglobulins, complement factors, fibrinogen, APOE, cholesterol, presenilins, cytokines (IL-1,IL-6, TGF-, TNF- ), intercellular adhesion molecule 1 (ICAM-1), clusterine, -synuclein, and inorganic elements [10]