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The goal of the 3R Principle is to avoid animal experiments altogether (Replacement) and to limit the number of animals (Reduction) and their suffering (Refinement) in tests to an absolute minimum

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It belongs to a class of drugs called sympathomimetic amines, which are similar to amphetamines

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Abstract Background Fibromyalgia (FM) as a prototypical nociplastic pain condition displays a difficult therapeutic situation in many cases

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