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Hruba et al., 2022) (Figure 2)

This may be one of the mechanisms underlying the effect of memantine in PD, as the K ATP channels on hippocampal neurons are composed of the same subunits as those on islet cells (Kir6.2 and SUR1) [186]

Explores the use of Homo-PROTACs for the chemical knockdown of cereblon, offering a novel strategy to selectively degrade cereblon and potentially enhance therapeutic approaches for diseases associated with its dysfunction