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In the ACL, oxidative stress can impair fibroblast function and promote ECM degradation

Collectively, research suggests that skeletal muscle aging is accompanied by increased susceptibility to ferroptosis, characterized by reduced GPX4 expression, altered iron handling (including TFRC decline) and heightened oxidative stress (39)

Whilst clinical evidence suggests potential benefits for gastric mucosal health, particularly when used alongside conventional treatments, it is not currently recommended in NICE guidance and should not replace appropriate medical investigation of persistent gastrointestinal symptoms

Reduced glucose uptake precedes insulin signaling defects in adipocytes from heterozygous GLUT4 knockout mice