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Specific instances of an effect of host Se deficiency on RNA viruses or associated diseases Coxsackie virus and Keshan disease In the 1990s, Beck and colleagues showed that Se deficiency in mice, with its associated low or absent activity of protective GPX1, caused mutations in a non-virulent stain of coxsackie virus B3 that lead to the development of a virulent strain that caused myocarditis, even in a subsequent mouse that was Se-sufficient (Reference Beck, Shi and Morris18)

Bibliography Khavinson VKh et al

Growth factor dependence of progression through G1 and S phases of adult rat hepatocytes in vitro

Norppa H, Tursi F, Pfaeffli P, Maeki-Paakkanen J, & Jaerventaus H (1985) Chromosome damage induced by vinyl acetate through in vitro formation of acetaldehyde in human lymphocytes and Chinese hamster ovary cells