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Glycine also contributes to the production of glutathione, a powerful antioxidant, and creatine, which supplies energy to muscles

Functional iron deficiency is commonly observed in chronic conditions, such as heart failure and chronic kidney disease [63, 101, 102]

Importantly, the cells response to injury can also vary in accordance with the level of stress (low versus high) and the length of exposure (acute versus chronic), such that young healthy cells may counter acute stress more formidably that aged cells, specifically effecting cellular processes including autophagy, phagocytosis, proteosomal degradation, toxic clearance and metabolism, among others

In principle, using inhibitory chelators would be a great strategy to prevent OH production