Investigations into exosome therapy for POF are predominantly in the preclinical phase, with encouraging outcomes in enhancing ovarian function through the mitigation of oxidative stress and apoptosis, as well as the stimulation of angiogenesis and follicle maturation (Kim and Kim 2024
MT1 and MT2, that are seven membranous G-Protein coupled receptors and modulate the intracellular concentrations of cyclic nucleotides (cAMP, cGMP) and their transduction pathways.13,14 However, studies have attributed the structural features of melatonin for its active role that endows it with direct free radical scavenging and augmentation of antioxidant enzymes in oxidative stress.15,16 Melatonin has been found to stimulate expression of antioxidant hemeoxygenase1 (HO-1) and anti-inflammatory cytokine (IL-10) in addition to mitigate the CD 19+ B cells concentration, pro-inflammatory cytokines and apoptotic process in idiopathic membranous nephropathy.17 Moreover, melatonin has been reported to effectively eradicate the renal oxidative stress induced by mercuric chloride, carbon tetrachloride, uranium, cadmium and chlorpryfos-ethyl.1822 However, there are continuous efforts to investigate the therapeutic potential of melatonin in treatment of drug-induced toxicities.2325 This review is aimed to explore the current state of the knowledge on melatonin's role and mechanisms in amelioration of drug-induced nephrotoxicity
Ojuederie OB, Babalola OO (2017) Microbial and plant-assisted bioremediation of heavy metal polluted environments: a review
78 SchwartzerJ
