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Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2'-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson's disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process

6.2 Mechanisms of action The antidepressant and neuroprotective properties of Ginkgo biloba are attributable to its multifaceted mechanisms of action (Figure 2)

Brain-derived Neurotrophic factor ( BDNF ) is essential for neurogenesis and extensively studied as a biomarker in psychiatry (Lin & Huang, Reference Lin and Huang2020) There is extensive evidence of a difference in DNAm in BDN F, as well as EWAS studies showing enrichment for the neurogenesis pathway in SCZ (Di Carlo et al., Reference Di Carlo, Punzi and Ursini2019