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Figure 1 The prevalence of hsCRP levels 2 mg/L This study found (Figure 2) that 24.4% (21/86) of patients on the DTG-based regimen and 44.2% (38/86) on the ATV/r-based regimen have increased hsCRP levels 2 mg/L

Third, GSNO interacts with E3 ubiquitin ligase C-terminus Hsc70 interacting protein (CHIP), inhibiting CHIP-CFTR interaction and reducing CFTR ubiquitination, which increases both mature and immature F508del-CFTR levels and enhances cell surface expression (Zaman et al., 2019)

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Table 3 Integrative framework of pathology, biomarkers and the therapeutic interventions