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doi:10.1016/j.jfms.2011.07.016 White JD, Stevenson M, Malik R, Snow D, Norris JM

This initial step is crucial and can be impaired in individuals with reduced gastric acid production, such as older adults or those taking proton pump inhibitors (PPIs) or H2-receptor antagonists

52 Interestingly, folate supplementation in isolation was found to be approximately one-third as effective as metformin in reducing insulin resistance and preventing T2DM 52 in the populations examined