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It is also worth noting that animal model studies have illustrated a mechanistic contribution of microbial TMA and TMAO generation to enhanced development of atherosclerosis, platelet reactivity and thrombosis, and both impairment in renal function and fibrosis, as well as adverse ventricular remodeling and heart failure (refs

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More comprehensive studies are needed to investigate the long-term effects of these diets and interventions and to what extent they are useful in clinical practice