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doi: 10.1016/j.anifeedsci.2022.115297 40 HeWRahimnejadSWangLSongKLuKZhangC

3.1.2 Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a metabolic disorder typically caused by mtDNA mutations in tRNA genes, predominantly by the A3243G mutation in the MT-TL1 gene, encoding for tRNA-Leu(UUR) (Yu-Ichi et al., 1990