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Furthermore, exposure to heavy metals, pesticides, and common household chemicals forces the liver to use up its glutathione "savings" to keep the body safe

4 integrates extracellular stress and growth cues to regulate cell-cycle progression, apoptosis, and differentiation, and frequently cooperates with NF-B signaling to promote cancer cell survival and metastasis

Probucol, a lipid-lowering agent, also exhibits antioxidant properties that reduce intracellular oxidative stress and maintain normal cellular redox state by upregulating Nrf2 and GPX4 protein expression, thereby enhancing cardiomyocyte antioxidant capacity