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However, while FEV 1 is the primary endpoint in most clinical trials of mucus-targeted therapies, it is insensitive to early or small airway mucus obstruction [48] and correlates poorly with mucus plug burden on imaging [11]

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320 Although all cystines located on the surface of p53 can be modified by the Michael addition reaction, cystine 124 is considered the most important site

Notably, the SAC-treated group was positioned between the control and model groups, deviating from the model group towards the control group along the PC1 direction, suggesting that SAC intervention partially reversed the metabolic disorders induced by the model condition