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Dhankecha Mayank Dineshbhai MBBS Last updated on 13th Jan, 2026 Introduction Pernicious anaemia is a type of vitamin B12 deficiency anaemia that occurs when the body cannot absorb enough vitamin B12 from food due to a lack of intrinsic factor, a protein made in the stomach

The combined four-component algorithm adjusts for age and folate status, in view of the likely increase in serum MAA with age in the elderly, and the increase in serum Hcy in folate deficiency

As described above, vitamin B12, in the form of methylcobalamin, is an essential co-factor for methionine synthase and the remethylation of homocysteine (Figure 2)

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