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We started by digging into a 2023 Lancet study that identified four industries responsible for more than a third of deaths globally due to their contributions to chronic diseases: tobacco, alcohol, ultraprocessed foods and fossil fuels

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On the other hand, its harder to make a strong case for harm when it comes to adults who smoke, since the continuum of harm becomes relevant, which opens up the narrative to the Harm Reduction Mindset

The final sample size was 541 participants for whom we could detect a difference of 1.5 units in means or 10% in proportion between exposed and non-exposed groups with a power of 80% and an alpha level of 0.05