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doi: 10.1073/pnas.1603111113CrossRefGoogle ScholarPubMed Carrozzino, D., Patierno, C., Fava, G

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Both ulcerative colitis and Crohns disease can present with extraintestinal manifestations, which may even precede symptoms in the gastrointestinal tissues

B12-downregulated genes in this group were related to positive regulation of transcription by RNA polymerase II, processing and transport of mRNA, mRNA splicing, cellular response to DNA damage stimulus, activation of innate immune response, positive regulation of IL-6 and IL-2 production, T-cell differentiation in thymus, histone modification, viral transcription and DNA conformational change