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The multifunctional docking site of MET recruits to the plasma membrane stereotypical adaptor/signaling molecules such as Gab1, Grb2, SPH2, phosphoinositide-3-kinase (PI-3K), Src, phospholipase c gamma (PLC), Shc, and signal transducer and activator of transcription 3 (STAT3) (Ponzetto et al., 1994

In addition, the authors thank Lindsay Uglow of Spirit Medical Communications Group Limited for medical writing and editorial assistance (funded by Novo Nordisk A/S) and Christin Lth Hertz of Novo Nordisk for reviewing the manuscript

For the CagriSema combination, gastrointestinal adverse events affected 79.6% of participants compared to 39.9% with placebo

500mcg TB-500 per capsule