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We assessed the effects of the drugs on the physiological status of diabetic mice by measuring blood glucose, body weight, and cell counts in several organs, as well as effects of thymulin and PRDX6 on the immune status of diabetic mice measuring concentrations of pro-inflammatory cytokines in blood plasma (TNF-, interleukin-5 and 17, and interferon-), activity of NF-B and JNK pathways, and Hsp90 expression in immune cells

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Peripheral IRS activation, evidenced by increased plasma levels of TNF- receptor subtype 1, IL-6, and IL-8, is significantly correlated with atypical brain metabolism, cortical atrophy, diminished cortical gray matter, compromised integrity of white matter tracts in mood-related neural networks, and altered functional connectivity and activation patterns of cerebral circuits [1, 209]

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