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For example, DFO decreased retinal iron deposition by 50% and increased photoreceptor survival by 1.8-fold in rd10 mice, and Fer-1 induced RGC and photoreceptor death by 60% and ERG b-wave amplitude recovery in rd1 mice

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The authors utilized genome-wide genotyping and subsequent genotype imputation to infer metabolic phenotypes, classifying individuals into poor (PM), intermediate (IM), normal (NM), and rapid/ultrarapid metabolizers (RM/UM) according to CPIC guidelines ( This approach allowed the translation of genetic polymorphisms into predicted enzymatic activities, although with notable limitations for CYP2D6, whose structural variantssuch as duplications and deletions that critically affect enzyme functioncannot be accurately imputed from standard SNP array data (Nofziger et al., 2020

The relative number of DAPI stained cells followed a similar pattern to Bd growth (Figure 4A,C)