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[59] Since both the oxidized and reduced forms of nicotinamide adenine dinucleotide are used in these linked sets of reactions, the cell maintains significant concentrations of both NAD + and NADH, with the high NAD + /NADH ratio allowing this coenzyme to act as both an oxidizing and a reducing agent

Lobaplatin (Table 1) is another third-generation platinum-based drug, which appears to have lower nephro- and ototoxicity than its predecessors