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DNA demethylation encompasses the removal of a methyl group (-CH3) from DNA and proceeds through two fundamental mechanisms: active demethylation, which implicates the TET enzyme family catalyzing the oxidation of the methyl group on cytosine, and passive demethylation, where DNA demethylase enzymes directly excise the methyl group from cytosine ( Figure 1 ) (3739)

IFN-related pathways were more enriched in the FMT nonresponder group, and IFN gene expression was negatively correlated with FMT therapeutic efficacy [77]

J Lipid Res 44:22702277