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Description

Chrysosplenetin acts as a homeostasis stabilizer with dual-function in shattering Plasmodium berghei K173 resistance to artemisinin driven by both ABC transporters and heme-ROS/GSH axis

doi: 10.1016/j.canlet.2021.09.033 40 LiuJXiaXHuangP

National Natural Science Foundation of China, 31971078

These death pathways share upstream triggers including mitochondrial dysfunction, ER stress, and redox imbalance, and often co-occur to amplify tissue injury and inflammation